Figure 6
From: 3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish
mRNA expression of genes associated with oxidative stress and ER stress. Relative mRNA expression of oxidative stress-related genes; nuclear factor erythroid 2 - related factor 2 (nrf2), superoxide dismutase 2 (sod2), glutathione S transferase pi 1 and 2 (gstp1/2), glutathione peroxidase 1a/4a (gpx1a, gpx4a), peroxiredoxin 4 (prdx4), and thioredoxin-like 1/4 (txnl1, txnl4) (A) and ER stress/UPR response related genes; activating transcription factor 4 (atf4), growth arrest and DNA-damage-inducible 45 alpha (gadd45a), inositol-requiring enzyme 1 (ire1), nuclear factor kappa-light-chain-enhancer of activated B cells (nfkb), X-box binding protein 1 (xbp1), spliced form of xbp1 (xbp1-s), activating transcription factor 6 (atf6), DNA damage-inducible transcript 3 (ddit3), ER degradation-enhancing alpha-mannosidase-like 1 (edem1), binding immunoglobulin protein (bip), DnaJ homolog subfamily C member 3 (dnajc3), glucose-regulated protein 94 (grp94), Bcl2 interacting mediator of cell death (bim), BH3-interacting domain death agonist a (bida), and Bcl2 associated x b (baxb) (B). Error bars indicate standard deviation of the mean. *P ≤ 0.05, **P ≤ 0.005.
