Figure 2

Activity-induced MEMRI in APPxPS1-Ki mice. (A) Representative illustration of T1-weighted images of mouse brains (coronal plane) after MnCl2 peripheral injection and behavioral stimulation. No obvious differences are observed between PS1-Ki and APPxPS1-Ki genotypes in terms of MR contrast. (B) Quantification of R1 relaxivity in different regions of interest in mice that underwent activity-induced MEMRI. Regardless of the brain region, no differences were obtained between PS1-Ki and APPxPS1-Ki mice.