Figure 7
From: FOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression
Combination treatment significantly inhibits tumour colony formation. (A–C) Clonogenic assays showing HCT116, DLD1 and HT29 cells lines treated with 5-FU (1 μg/ml) and thiostrepton (Thio) (1 μM) alone or in combination for 72 hours, followed by media replacement and culture for 14 days. The combination of 5-FU and thiostrepton significantly decreases colony formation in HCT116, DLD1 and HT29 cells. Data were represented as mean ± SD (n = 3). ***p < 0.0001. (D) 5-FU and thiostrepton combination significantly decreases migration of colorectal cancer cells, HCT116. Data were represented as mean ± SD (n = 2) (5-FU with combination p < 0.0001, thiostrepton with combination p < 0.0001).
