Figure 8
From: FOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression
Combination treatment induces caspase-dependent apoptosis in colon cancer cells. Cellular caspase 3/7 activity measured in HCT116, DLD1 and HT29 cells following treatment with 5-FU (1 μg/ml) and thiostrepton (1 μM) alone or in combination for 48 and 72 hours. Data were represented as mean ± SD (n = 3). (A) 5-FU and thiostrepton combination significantly increased apoptosis compared to either agent alone or control HCT116 48 hours (p < 0.0001); HCT116 72 hours (p < 0.006). (B) DLD1 48 hours (p < 0.006); 72 hours (p < 0.0001). (C) HT29 48 hours (p < 0.005); 72 hours (p < 0.0001).
