Table 2 The amino acid change sites of HA1 and NA of influenza B/Yamagata-lineage virus.

From: Molecular evolution of influenza B virus during 2011–2017 in Chaoyang, Beijing, suggesting the free influenza vaccine policy

Representative strain

HA1

NA

116

172

211

251

278

298

312

41

42

45

49

62

73

295

342

*B/Wisconsin/1/2010

N

L

K

M

R

K

E

S

Q

I

I

A

L

R

D

B/Beijing-Chaoyang/56/2011

K

—

—

—

—

E

K

—

—

—

—

—

—

—

—

B/Beijing-Chaoyang/469/2012

K

—

—

—

—

E

K

—

—

—

—

—

—

—

—

*B/Massachusetts/2/2012

N

L

K

M

R

K

E

S

Q

I

I

A

L

R

D

B/Beijing-Chaoyang/326/2013

K

—

—

—

K

E

K

P

S

—

T

—

—

S

G

B/Beijing-Chaoyang/1327/2014

K

—

—

—

K

E

K

P

S

—

T

—

—

S

G

B/Beijing-Chaoyang/930/2015

K

Q

R

V

—

E

K

—

—

V

—

T

P

—

N

*B/Phuket/3073/2013

K

L

K

M

R

E

K

S

R

V

I

A

P

S

D

B/Beijing-Chaoyang/820/2016

—

Q

—

V

—

—

—

—

—

—

T

T

—

R

N

B/Beijing-Chaoyang/1240/2017

—

Q

—

V

—

—

—

—

—

—

M

T

—

R

N

  1. * represents vaccine virus strains. “—” represents the same amino acids comparing to the same region of vaccine virus strains.
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