Figure 1 | Scientific Reports

Figure 1

From: Glatiramer Acetate modulates ion channels expression and calcium homeostasis in B cell of patients with relapsing-remitting multiple sclerosis

Figure 1

MANTRA analysis of gene expression profiles obtained from patients’ B cells following acute in vitro or chronic in vivo treatment with glatiramer acetate. (A) Schematics of experiment. (B,C) MANTRA analysis. The triangle represents glatiramer acetate (GA) and edges connecting GA to circles represent drugs inducing a similar transcriptional profile according to the Connectivity Map. The top 15 most similar drugs are shown for the acute in vitro (B), and for the chronic in vivo treatment (C). Compounds distances from GA were equal or less than 0.8. Node colors indicate communities.

Back to article page