Figure 5

Beat to beat analysis of whole guinea pig heart. (a) Tissue averaged fluorescent signal from voltage dye loaded guinea pig heart across 70 s experiment. (b) Graph of whole heart beat-to-beat changes in mean APD50. (c) Raw trace and whole heart APD50 maps prior to (beats 47 & 48) and immediately after (beats 49–52) pacing frequency increase from 5 Hz to 8 Hz (blue in A and B). (d) Raw trace and whole heart APD50 maps prior to (beats 300 & 301) and immediately after (beats 302–305) pacing frequency return to 5 Hz.