Table 4 Bivariate quantitative genetic analyses of HRV, HR and BRS with office beat-to-beat resting SBP/DBP examining the genetic, environmental, and phenotypic correlations.

	N	Office beat-to-beat SBP				Office beat-to-beat DBP
	N	Genetic correlation, r_G(SE)	Environmental correlation, r_E(SE)	Phenotypic correlation, r_P	Proportions of r_P (A/E)	Genetic correlation, r_G(SE)	Environmental correlation, r_E(SE)	Phenotypic correlation, r_P	Proportions of r_P (A/E)
lnSDNN	1155	0.06 (0.20)	−0.10^* (0.05)	−0.07^§	0.12/0.88	−0.01 (0.20)	−0.07(0.05)	−0.06^§	0.03/0.97
lnRMSSD	1155	−0.01 (0.19)	−0.14^* (0.05)	−0.12^§	0.02/0.98	−0.09 (0.20)	−0.11^* (0.05)	−0.10^§	0.15/0.85
lnHF	1126	0.20 (0.20)	−0.17^* (0.05)	−0.09^§	0.23/0.77	0.17 (0.20)	−0.14^* (0.05)	−0.08^§	0.22/0.78
lnLF	1126	0.16 (0.20)	−0.08(0.05)	−0.03	0.31/0.69	0.22 (0.21)	−0.07(0.05)	−0.02	0.40/0.60
lnVLF	1126	0.22 (0.22)	−0.08(0.05)	−0.03	0.35/0.65	0.19 (0.22)	−0.06(0.05)	−0.02	0.36/0.64
lnTP	1126	0.22 (0.21)	−0.12^* (0.05)	−0.06^§	0.28/0.72	0.22 (0.22)	−0.10^* (0.05)	−0.05	0.30/0.70
lnHR	1155	0.29 (0.14)	0.17^* (0.05)	0.20^§	0.40/0.60	0.39^† (0.14)	0.14^* (0.05)	0.21^§	0.50/0.50
lnBRS	1124	−0.22(0.18)	−0.10 (0.05)	−0.13^§	0.39/0.61	−0.17(0.19)	−0.08 (0.05)	−0.10^§	0.36/0.64

Models were adjusted for age, sex, BMI, age², age × sex, and age² × sex.
SBP: systolic blood pressure; DBP: diastolic blood pressure; r_G: genetic correlation; r_E: environmental correlation; r_P: phenotypic correlation; SE: standard error; SDNN: standard deviation of normal-to-normal intervals; RMSSD: root mean square of successive differences; HF: high frequency; LF: low frequency; VLF: very low frequency; TP: total power; HR: heart rate; BRS: baroreceptor sensitivity.
^†Genetic correlations are significantly different from 0 (p < 0.05).
*Environmental correlations are significantly different from 0 (p < 0.05).
^§Phenotypic correlations are significantly different from 0 (p < 0.05).
A/E is the percentage of the phenotypic correlation that is caused by genes (A) or environment (E), based on the following equation: \({r}_{p}=(\sqrt{{h}_{BP}^{2}}\times {r}_{G}\times \sqrt{{h}_{HRV}^{2}})+(\sqrt{{e}_{BP}^{2}}\times {r}_{E}\times \sqrt{{e}_{HRV}^{2}})\).

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