Figure 3 | Scientific Reports

Figure 3

From: Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression

Figure 3

CycT suppresses the growth of NSCLC orthotopic tumor xenografts. (A) Representative bioluminescence images of mice bearing orthotopic H1299 tumor xenografts treated with saline (control), cyclopamine tartrate CycT (7.5 mg/kg, I.V.), bevacizumab (Bev, 5 mg/kg, I.P.), and SA (50 mg/kg, I.V.) every 3 days. n = 6/group. (B) The quantified luminescence signals representing tumor volumes. Data are plotted as mean ± standard deviation. For statistical analysis, the levels in treated tumors were compared to the levels in control tumors with a Welch 2-sample t-test. *p-value < 0.05; **p-value < 0.005. (C) Representative H&E images of control tumors and tumors treated with CycT, Bev or SA. Tumors are marked with light blue outlines. Montage (scale bar: 1 mm), 10X (scale bar: 100 µm), and 40X (scale bar: 20 µm) images of the H&E sections are shown from left to right. The light blue rectangles in Montage and 10X denote the regions shown in 10X and 40X, respectively. (D) The body masses of mice under every treatment condition.

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