Figure 6 | Scientific Reports

Figure 6

From: Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression

Figure 6

CycT diminishes levels of OXPHOS regulators and glycolytic enzymes. The effects of CycT on the levels of OXPHOS-promoting regulators MYC (A) and MCL1 (B) and on the levels of hexokinase II (C) and pyruvate dehydrogenase (D) in NSCLC tumors. Data are plotted as mean ± SEM. For statistical analysis, the levels in treated tumors were compared to the levels in control tumors with a Welch 2-sample t-test. **p-value < 0.005. HK2: hexokinase II; PDHA1: pyruvate dehydrogenase. IHC images are representative of 3 independent experiments.

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