Figure 5
From: DNA demethylation is associated with malignant progression of lower-grade gliomas
Genomic profile of 17 initial gliomas and 19 corresponding recurrent tumors. (a) The numbers of non-synonymous mutations in initial tumors and recurrent tumors in each case are shown at the top. When one case had two recurrences (MT2 and MT20), the second recurrence date is shown. WHO grade of initial and recurrent tumors and treatments performed after the first operation are shown in the middle. The mutation signatures are shown at the bottom. Tx treatment, TMZ temozolomide, PAV procarbazine, nimustine, and vincristine, ACNU nimustine, RT radiotherapy. (b) Representative cancer-related non-synonymous mutations and CNAs of 17 initial tumors and 19 recurrent tumors are shown. Sample information is shown at the top. The types of alterations are indicated as colored boxes. Indel insertion and deletion.
