Figure 7
From: DNA demethylation is associated with malignant progression of lower-grade gliomas
Schematic overview of DNA demethylation during glioma progression. (a) Somatic mutations, CNAs, genomic fusion, and demethylation in the promoter and enhancer of RB, PI3K-AKT or MAPK pathway genes upregulate cell cycle and cell growth-related genes, which accelerate cell division and lead to passive demethylation preferentially in late-replicating regions. Upregulated genes by the demethylation such as IGF2BP3 further accelerates cell division. (b) When DNA replicates, the methylation pattern is maintained by DNA methyltransferase (DNMT1) by copying it to daughter strands. However, in vigorously dividing cells, passive demethylation may occur at late-replicating regions due delayed maintenance of methylation.
