Table 2 Association of Alcohol Consumption with Baseline Telomere Length.

Heart and Soul (n = 948)
Model ^a	Beta Coefficient (95% CI)	P Value
Unadjusted	−0.04 (−2.58, 2.50)	0.98
Age-adjusted	−1.00 (−3.52, 1.53)	0.44
Model 1	−1.38 (−3.91, 1.16)	0.29
Model 2	−1.09 (−4.06, 1.89)	0.66
Model 3	−1.34 (−4.33, 1.66)	0.38
Model 4	−1.64 (−4.67, 1.39)	0.29
Cardiovascular Health Study (n = 1673)
Model ^b	Beta Coefficient (95% CI)	P Value
Unadjusted	−7.53 (−13.56, −1.49)	0.015
Age-adjusted	−7.43 (−13.35, −1.51)	0.014
Model 1	−3.25 (−9.20, 2.70)	0.29
Model 2	−2.40 (−8.47, 3.67)	0.44
Model 3	−3.24 (−9.99, 3.51)	0.35
Model 4	−1.46 (−9.11, 6.18)	0.71

Alcohol consumption was modeled continuously in drinks per week; telomere length was measured in basepairs.
^aAge-adjusted model was adjusted for baseline (year 1) age. Model 1 was adjusted for age, sex, and race. Model 2 = Model 1 + BMI, waist-hip ratio, smoking status, and number of pack years. Model 3 = Model 2 + diabetes, hypertension, previous myocardial infarction, and heart failure. Model 4 = Model 3 + C-reactive protein, interleukin-6, fibrinogen, docosahexaenoic acid, and eicosapentaenoic acid.
^bAge-adjusted model was adjusted for baseline (year 5) age. Model 1 was adjusted for age, sex, and race. Model 2 = Model 1 + BMI, waist-hip ratio, kilocalories of physical activity, and smoking status. Model 3 = Model 2 + diabetes, hypertension, coronary artery disease, prior myocardial infarction, heart failure, prior stroke, and liver disease. Model 4 = Model 3 + C-reactive protein, interleukin-6, fibrinogen, docosahexaenoic acid, and eicosapentaenoic acid.

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