Table 3 Association of Alcohol Consumption with Change in Leukocyte Telomere Length Over 5 Years.

From: Alcohol consumption and leukocyte telomere length

Modela

Beta Coefficient (95% CI)

P Value

Heart and Soul (n = 606)

Unadjusted

−0.93 (−3.07, 1.21)

0.40

Age-adjusted

−1.41 (−3.47, 0.65)

0.18

Model 1

−0.60 (−2.66, 1.47)

0.57

Model 2

−0.20 (−2.57, 2.17)

0.87

Model 3

−0.36 (−2.75, 2.03)

0.77

Model 4

−0.41 (−2.84, 2.02)

0.74

  1. Alcohol consumption was modeled continuously in drinks per week.
  2. Change in telomere length in basepairs was defined as the residual of the regression of 5-year change in telomere length on baseline telomere length.
  3. aAge-adjusted model was adjusted for baseline (year 1) age. Model 1 was adjusted for age, sex, and race. Model 2 = Model 1 + BMI, waist-hip ratio, smoking status, and number of pack years. Model 3 = Model 2 + diabetes, hypertension, previous myocardial infarction, and heart failure. Model 4 = Model 3 + C-reactive protein, interleukin-6, fibrinogen, docosahexaenoic acid, and eicosapentaenoic acid.
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