Figure 2 | Scientific Reports

Figure 2

From: Single Cell Profiling Reveals PTEN Overexpression in Influenza-Specific B cells in Aging HIV-infected individuals on Anti-retroviral Therapy

Figure 2

Transcriptional signatures of H1N1-specific B cells in HIV-infected individuals compared to Healthy controls. (A) Log fold change expression of differentially expressed genes in single cells from HIV and healthy controls (HC) with FDR-adjusted p value < 0.05 using MAST analysis. Red bars indicate higher expression in HIV and gray bars indicate higher expression in HC. (B) Upstream regulator analysis (C) Network analysis and (D) Pathway analysis using Ingenuity Pathway Analysis software shows top results using the 14 differentially expressed genes between HIV and HC identified in A. In C, Red color indicates higher expression in HIV-infected and green color indicates lower expression in HIV. (E) Scatter plot showing log 2 expression levels of PTEN gene expression for each single cell from HC (Red) and HIV (blue). (F) Pie charts showing proportion of cells with detectable PTEN expression in HIV and HC.

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