Figure 4 | Scientific Reports

Figure 4

From: Single Cell Profiling Reveals PTEN Overexpression in Influenza-Specific B cells in Aging HIV-infected individuals on Anti-retroviral Therapy

Figure 4

Memory B cell Ig Isotype expression of H1N1-specific B cells. (A) Overlay dot plots showing Ig isotype distribution of IgM (y-axis) and IgG (x-axis) for all study participants in total IgD- B cells (small gray dots, underlay) and H1N1-specific IgD- B cells (large blue dots, overlay). Numbers in quadrants refer to frequency of cells in H1N1-specific population. (B) Summary of data for H1N1-specific B cells from (A) is shown for HC and HIV participants. (C) Frequencies of IgM memory B cells (IgD− fraction) within each subset are shown for HC and HIV participants following 5 day in vitro culture of PBMC with H1N1 antigen. Student’s t test was performed between groups indicated, **denotes.

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