Figure 2

Sensitivity of network metrics to thresholding in parametric and permutation tests. False positive rates (FPRs) are reported as function of different thresholding. The minimum value of correlation in the PET covariance matrix above statistical significant threshold (p-value < 0.05) is also explicitly indicated. As shown by the figure, this value is not constant as it depends on the number of data points used to compute the interregional correlations, which corresponds to the number of subjects used to define the PET adjacency matrix (40 for [¹⁸F]FDG, 25 for [¹⁸F]FDOPA and 30 for [¹¹C]SB207145). Blue lines refer to node strength, red lines refer to clustering coefficient. Mean and variance analysis are reported in solid and dashed lines respectively. Number of ROIs is 23 for [¹⁸F]FDG, 45 for [¹⁸F]FDOPA and 67 for [¹¹C]SB207145.