Figure 3
From: Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion
Ang-(1-7) does not influence RAS mRNA expression at 24 hr or 7 days post MCAO in peri-infarct regions. (a) Atgr1a levels were comparable to sham at 24 hr and 7 days post MCAO without Ang-(1-7) treated effects. (b) Atgr2 mRNA expression did not alter at 24 hr post MCAO when compared to sham. However, at 7 days reperfusion, gene expression were significantly upregulated in MCAO-vehicle group. (c) Mas1 was comparable to sham levels 24 hr post MCAO; yet, at 7 days post MCAO, levels were significantly downregulated in MCAO groups without Ang-(1-7) mediated effects. (d,e) Ace and Ace2 were comparable to sham at 24 hr and 7 days post MCAO. Data displays values for sham (n = 6-7); MCAO-Vehicle (aCSF) (n = 7–9) and MCAO-Ang-(1-7) (n = 7–9) treated rats. Data are presented as mean ± S.D. **P < 0.01 compared to sham; one-way ANOVA with Tukey’s posthoc test.
