Figure 4
From: Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion
Ang-(1-7) significantly attenuates Nox1 gene expression to sham levels 7 days post MCAO in peri-infarct regions. (a) Nox1 was comparable to sham at 24 hr for MCAO-Vehicle and MCAO-Ang-(1-7) treated groups. Conversely, at 7 days post MCAO, Nox1 was significantly decreased in MCAO-Vehicle group with Ang-(1-7) treatment attenuating the expression to sham levels (P < 0.05). (b) Nox2 expression did not alter at 24 hr or 7 days post MCAO when compared to sham. (c–h) Il1b, Il6, Nos2, Itgam, Ptgs2 or Nfkb1 expression was not influenced by Ang-(1-7) therapy at 24 hr and 7 days post MCAO. Data displays values for sham (n = 6–7); MCAO-Vehicle (aCSF) (n = 7–9) and MCAO-Ang-(1-7) (n = 7–9) treated rats. Data are presented as mean ± S.D. *P < 0.05 compared to sham; #P < 0.05 compared to MCAO-Vehicle; one-way ANOVA with Tukey’s posthoc test.
