Table 3 Association of parental history of T2D with T2D using ULR models*.

From: Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study

Parental history of T2D

Controls % (n)

Cases % (n)

Univariate Logistic Regression

r2

OR (95CI)

Main case-control study

Father

  negative

86.1 (837)

69.7 (747)

0.052e

1

  positive

13.9 (135)

30.3 (324)e

2.69e (2.15–3.36)

Mother

  negative

79.6 (774)

55 (589)

0.09e

1

  positive

20.4 (198)

45 (482)e

3.2e (2.63–3.9)

Both parents

  0

70.3 (683)

41.4 (443)

0.121e

1

  1

25.2 (245)

42 (450)

2.83e (2.33–3.45)

  2

4.5 (44)

16.6 (178)

6.24e (4.39–8.86)

Total

100 (972)

100 (1071)e

 

Replica case-control study

Father

  negative

82.9 (344)

67.6 (1667)

0.026e

1

  positive

17.1 (71)

32.4 (799)e

2.32 (1.77–3.04)e

Mother

  negative

76.4 (317)

52.7 (1306)

0.052e

1

  positive

23.6 (98)

47.3 (1170)e

2.9 (2.28–3.68)e

Both parents

  0

63.4 (263)

36.8 (905)

0.073e

1

  1

32.5 (135)

47.2 (1161)

2.5 (2–3.13)e

  2

4.1 (17)

16 (394)e

6.74 (4.07–11.16)e

Total

100 (415)

100 (2460)

 
  1. r2 = Nagelkerke method.
  2. *The power (1-β err prob) >0.95 for all univariate logistic regression (ULR) models.
  3. p-value for frequency distribution was calculated with the Pearson chi-square test, for r2 with the Omnibus test, and for OR with the Wald test. The p-values are indicated with super indices as follows: ap > 0.05, bp < 0.05, cp < 0.01, dp < 0.001 and ep < 0.0001.
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