Figure 1
From: Early overnutrition reduces Pdx1 expression and induces β cell failure in Swiss Webster mice
Effects of early overnutrition in pups. Body weight in male (a) and female (b) pups from postnatal day (P) 2 until weaning at P21 (n = 18–19 for males, n = 7–8 for females). Non-fasted plasma insulin (c) and plasma leptin (d) in P11 males. Non-fasted blood glucose (e), epididymal white adipose tissue (eWAT) weight (f), and full stomach weight (g) in P10, 14, and 21 male pups. β cell mass (h) and β cell mass normalized to body weight (i) in P14 male pups. Pancreatic insulin content (j) in P21 male pups. Data in (a) and (b) represent median ± interquartile range. Box and whisker plots (c–g, j) represent the interquartile range (box) and minimum to maximum values (whiskers), with line at the median. Floating bars (h,i) represent the range of values with line at the median. Analyses by two-way repeated measures ANOVA with Bonferroni post-hoc (a,b), two-way ANOVA with Bonferroni post-hoc (e–g), or unpaired t-test (c,d,h–j); *p < 0.05, ***p < 0.0005.
