Figure 4
From: Identifying Windows of Susceptibility by Temporal Gene Analysis
SWOT clocks related to Microcephaly. (A) SWOT clock for Microcephaly associated genes. (B) SWOT clock for genes associated with the ‘Spliceosome’ and (C) ‘Cell Cycle’ (KEGG pathway database). Both the ‘Cell Cycle’ and ‘Spliceosome’ clock demonstrates a similar profile to the SWOT clock for Microcephaly. The initials for enriched stages in each SWOT clock are stated. All gene disease associations are from derived from the Diseases database (http://diseases.jensenlab.org/Search) unless otherwise stated. Legend: Pluripotency (PP); Neuroectoderm (NE), Neural Differentiation (ND), Cortical Specification (CS), Deep Layers (DL), Upper Layers (UL). Significant enrichment or depletion is based on a FDR adjusted p-value < 0.1.
