Table 1 Highlighted disease for WOS identification with Swot Clock.

From: Identifying Windows of Susceptibility by Temporal Gene Analysis

Disease/Pathway

 

Pluripotency

Neuroectoderm

Neural Differentiation

Cortical Specification

Deep Layers

Upper Layers

ASD

log odds

−0.6105

−0.6856

0.3684

0.3429

−0.1548

0.5814

fdr

0.0006

0.0008

0.0497

0.0529

0.5053

0.0000

SFARI ASD

log odds

−0.782

−0.1037

0.2052

0.5521

0.6255

0.08299

fdr

0.0084

0.7371

0.7371

0.018

0.7371

0.7371

ASD Study

log odds

−0.04536

−0.2711

−0.5014

0.8136

0.06404

−0.2652

fdr

1

0.8991

0.8991

0.0858

1

0.8991

ASD Study D11

log odds

0.1489

−1.234

0.3796

−0.293

−0.49

0.6644

fdr

0.329

3.22E-07

0.05565

0.21828

0.0565

1.56E-05

ASD Study d31

log odds

0.03817

−0.9796

0.1687

−0.1863

−0.2289

0.665

fdr

0.6569

2.83E-14

0.1626

0.1626

0.1544

5.97E-14

Schizophrenia

log odds

−0.5267

−0.6698

0.2424

0.1266

0.0159

0.656

fdr

0.0004

0.0003

0.1689

0.4638

0.9346

0.0000

Schizophrenia Study

log odds

−0.09114

0.06393

0.0136

−0.01265

−0.6167

0.3459

fdr

1

1

1

1

0.0498

0.0582

Microcephaly

log odds

−0.02455

1.082

−0.1372

−0.2407

−0.6943

−1.057

fdr

0.9318

4.05E-11

0.7734

0.57405

0.0332

0

Spliceosome

log odds

−0.1351

2.363

−1.331

−1.492

−3.219

−3.748

fdr

0.7122

4.71E-26

0.0139

0.0039

0

2.38E-08

ZIKV Infection

log odds

−0.1089

0.5893

−0.3573

−0.1085

−0.0213

−0.2774

fdr

0.4608

4.28E-08

0.0484

0.57036

0.9463

0.0484

ZIKV Up

log odds

0.3762

−0.9827

−0.7971

0.5256

0.4118

−0.2389

fdr

0.0348

0.0006

0.0184

0.5256

0.4118

0.291

ZIKV Down

log odds

−0.4443

1.345

−0.3621

−0.8335

−0.2096

−0.6638

fdr

0.0054

1.03E-25

0.11148

0.0004

0.3156

0.0004

ZIKV + Microcephaly

log odds

−0.6459

3.227

−1.983

−2.144

−2.039

−2.568

fdr

0.2716

7.92E-13

0.0828

0.0828

0.0828

0.0165

ZIKV + Expanded Microcephaly Network

log odds

−0.8777

3.459

−2.181

−2.341

−2.237

−2.765

fdr

0.1067

7.92E-17

0.03408

0.03408

0.03408

0.0042

  1. The log odds and FDR corrected p-values after Fischer exact test across time for Swot Clocks throughout the study. Bolded text represents a significant enrichment based on an FDR adjusted p-value < 0.01.
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