Table 1 Body weight and blood parameters.

From: A new hyperpolarized 13C ketone body probe reveals an increase in acetoacetate utilization in the diabetic rat heart

 

Control

GK

P value

Body weight (g)

479.8 ± 30.0

403.3 ± 16.5***

<0.0001

Fasting values

Blood glucose (mM)

5.3 ± 0.5

9.3 ± 1.1***

<0.0001

Blood β-OHB (mM)

1.1 ± 0.2

1.1 ± 0.3

0.580

Blood TG (mM)

 2.0 ± 0.3

2.5 ± 0.7*

0.049

Fed values

Blood glucose (mM)

7.6 ± 1.2

12.6 ± 3.0***

<0.0001

Blood β-OHB (mM)

0.3 ± 0.1

0.4 ± 0.1

0.540

Serum acetoacetate (mM)

0.52 ± 0.02

0.55 ± 0.02**

0.002

Total ketone bodies (mM)

0.86 ± 0.11

0.92 ± 0.08

0.185

Serum insulin (fed, μg/L)

9.3 ± 3.7

3.2 ± 1.6**

0.001

Serum glucagon (fed, pM)

54.9 ± 29.8

57.1 ± 25.5

0.867

  1. β-OHB: β-hydroxybutyrate; TG: triglycerides; total ketone bodies: β-OHB + acetoacetate. Glucose, fasting β-OHB, and TG were measured at 20 weeks of age, while fed β-OHB, acetoacetate, insulin, and glucagon were measured at sacrifice. Data are means ± SD (control n = 10 and GK rats n = 9). *P < 0.05, **P < 0.01, ***P < 0.001.
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