Table 1 Simulation test on bimodal deuterated distributions.
From: deMix: Decoding Deuterated Distributions from Heterogeneous Protein States via HDX-MS
Distance between two deuterated numbers in a bimodal distribution | ||||||||
|---|---|---|---|---|---|---|---|---|
Weight | 2 | 3 | 5 | 8 | ||||
Initial | Expanded | Initial | Expanded | Initial | Expanded | Initial | Expanded | |
(a) For peptides of length 10 | ||||||||
0.5 | 49% | 100% | 80% | 100% | 100% | 100% | 100% | 100% |
0.6 | 68% | 100% | 83% | 100% | 98% | 100% | 100% | 100% |
0.7 | 37% | 100% | 86% | 100% | 92% | 100% | 100% | 100% |
0.8 | 24% | 100% | 58% | 100% | 91% | 100% | 100% | 100% |
0.9 | 18% | 100% | 42% | 98% | 92% | 100% | 100% | 100% |
(b) For peptides of length 15 | ||||||||
0.5 | 54% | 100% | 79% | 100% | 100% | 100% | 100% | 100% |
0.6 | 45% | 100% | 85% | 100% | 100% | 100% | 100% | 100% |
0.7 | 23% | 100% | 71% | 100% | 100% | 100% | 100% | 100% |
0.8 | 18% | 100% | 53% | 100% | 100% | 100% | 100% | 100% |
0.9 | 19% | 100% | 43% | 100% | 89% | 94% | 100% | 100% |
(c) For peptides of length 20 | ||||||||
0.5 | 48% | 100% | 75% | 100% | 100% | 100% | 100% | 100% |
0.6 | 29% | 100% | 74% | 100% | 100% | 100% | 100% | 100% |
0.7 | 21% | 100% | 54% | 100% | 99% | 99% | 100% | 100% |
0.8 | 18% | 100% | 45% | 100% | 99% | 100% | 100% | 100% |
0.9 | 18% | 100% | 42% | 100% | 83% | 97% | 100% | 100% |
(d) For peptides of length 30 | ||||||||
0.5 | 14% | 100% | 67% | 100% | 99% | 100% | 100% | 100% |
0.6 | 21% | 100% | 56% | 100% | 99% | 100% | 100% | 100% |
0.7 | 19% | 100% | 47% | 100% | 97% | 98% | 100% | 100% |
0.8 | 17% | 100% | 43% | 100% | 87% | 94% | 100% | 100% |
0.9 | 24% | 100% | 42% | 100% | 75% | 92% | 100% | 100% |
