Figure 7 | Scientific Reports

Figure 7

From: Renal Damaging Effect Elicited by Bicalutamide Therapy Uncovered Multiple Action Mechanisms As Evidenced by the Cell Model

Figure 7

Expression of signaling proteins and Annexin V% affected by testosterone and bicalutamide. (a) PI3K and Akt proteins. (b) The expression of p-Akt and total Akt when treated as indicated. (c) Apoptotic effect of SC79 and a combination of SC79 plus MK2206. The dose(s) used were: testosterone (T) 100 nM; bicalutamide (7.5, 15, 30 and 60 μM); SC79 10 μM, and MK2206 1 μM. Triplicate experiments were statistically treated. Data expressed in mean ± S.D. (n = 3).

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