Figure 1
Circadian expression of the human white adipose tissue transcriptome. Temporal expression profiles measured in five six-hourly white adipose tissue biopsies collected from seven participants in constant routine conditions. (A) Heatmap showing the mixed model values at averaged DLMO times (average per sampling point across subjects). Red represents high expression, blue low expression. (B) The average of z-scored mixed model profiles per cluster was calculated. Lines represent the average profile of all probes within each cluster. (C) Histogram of peak time estimates of probes identified as exhibiting circadian rhythmicity. Peak times were derived from the mixed modelling. (D,E) Representative profiles of probes exhibiting either (D) morning and (E) evening peak expression. Thin black lines show each participant’s gene expression profile plotted according to their own DLMO. The red thick line depicts the sinusoidal model fit and the blue thick vertical line indicates estimated peak time.
