Figure 5
Predicted rhythmicity of the mitochondrial short-chain, fatty acid elongation pathway. The activity of metabolic reactions in a metabolic model was assessed using the ‘Fast iMAT’ algorithm of MUFINS using averaged transcriptome samples and the human metabolic model Recon2 as input. For each reaction within the metabolic model we obtained a predicted metabolic activity profile across the circadian cycle. EC numbers represent specific enzymatic reactions. Circles and boxes indicate metabolites and reactions, respectively. Red boxes indicate reactions that were identified as rhythmic. Lines next to each circadian reaction indicate the dynamics (high or low) for each reaction across each of the five biopsy time points.
