Table 2 Univariate and multivariate Cox regression analyses of the TCGA-LIHC, LEC, and KOREAN cohorts.
From: NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma
Clinical variable | HR (95% CI) | p valuea | HR (95% CI) | p valuea | HR (95% CI) | p valuea |
|---|---|---|---|---|---|---|
Univariate Analysis | TCGA-LIHC | LEC | KOREAN | |||
20-NDMT Signature (NDMTs vs. Non-NDMTs) | 2.9 (1.8–4.8) | <0.001 | 1.9 (1.1–3.1) | 0.015 | 2.3 (1.1–5.1) | 0.035 |
Sex (Male vs. Female) | 0.7 (0.5–1.2) | 0.225 | 1.4 (0.8–2.3) | 0.227 | 1.1 (0.4–2.9) | 0.828 |
Age, years (≥50 vs <50) | 1.2 (0.6–2.2) | 0.582 | 0.7 (0.4–1.1) | 0.148 | 0.9 (0.4–2.0) | 0.726 |
Cirrhosis (Yes vs No) | 0.8 (0.4–1.7) | 0.535 | 1.4 (0.9–2.2) | 0.191 | 2.3 (0.8–6.4) | 0.128 |
AFP (>400 ng/ml vs ≤400 ng/ml) | 1.1 (0.6–2.0) | 0.836 | 1.4 (0.9–2.4) | 0.161 | 1.3 (0.6–2.9) | 0.501 |
Microvascular invasion (Yes vs No) | 1.3 (0.8–2.2) | 0.334 | 1.4 (0.6–3.3) | 0.398 | 3.2 (1.5–6.9) | 0.003 |
TNM staging (II + III vs I) | 2.1 (1.3–3.6) | 0.005 | NA | NA | 2.2 (1.0–4.8) | 0.046 |
BCLC Staging (B&C vs A) | 3.1 (1.5–6.3) | 0.002 | 0.7 (0.2–2.9) | 0.595 | 2.0 (0.7–5.5) | 0.167 |
Tumor size (>3 cm vs ≤3 cm) | NA | NA | 1.5 (0.7–3.2) | 0.329 | 1.8 (0.7–4.7) | 0.233 |
Histological grade (II-IV vs I) | 1.1 (0.5–2.3) | 0.790 | 0.5 (0.1–2.0) | 0.322 | NA | NA |
Child-Pugh class (B vs A) | 2.1 (0.9–5.1) | 0.101 | NA | NA | NA | NA |
Multivariate Analysis b | ||||||
20-NDMT Signature (NDMTs vs. Non-NDMTs) | 2.6 (1.3–5.1) | 0.005 |  |  |  |  |
BCLC staging (B&C vs A) | 3.1 (1.5–6.3) | 0.002 |  |  |  |  |
Multivariate Analysis c | ||||||
20-NDMT Signature (NDMTs vs. Non-NDMTs) | 2.6 (1.5–4.5) | p < 0.001 |  |  |  |  |
TNM staging (II + III vs I) | 2.1 (1.2–3.5) | 0.006 |  |  |  |  |
