Figure 8 | Scientific Reports

Figure 8

From: HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503

Figure 8

Proposed working model. The scheme illustrates the proposed sequence of events during a shift from HER2 only to p95HER2 expressing breast cancer. ‘‘alt. transl. start’’: alternative translation startsite, one of the pathways through which p95HER2 expression may be increased in breast cancer (the other being protease-activated shedding of the extracellular domain). See text for details.

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