Table 2 A final model of specific baseline parameters associated with ALSFRS-r progression.

From: A ferroptosis–based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis

Factors at baseline

Effect on ALSFRS-r progression

Coefficient β ± SE

p

NfLa

−0.02 (0.005)

0.004

4-HNEa

−0.11 (0.02)

<0.001

8-OHdG

−0.01 (0.004)

<0.001

Ferritina

−0.01 (0.002)

<0.001

  1. All parameters associated with ALSFRS-r progression from the adjusted models shown in Table 1 (interaction with time < 0.10) were included in a multivariable linear mixed model. Neurological parameters were removed manually using the same backward selection approach. The multivariate analysis was performed on the population for specific parameters using the final mixed model. aa coefficient corresponding to the effects of a 10 point increase. Analysis was adjusted for treatment and pre-specified baseline factors with their interactions to time (BMI, MMT, SVC, sodium and time since the onset of signs).
  2. Examples of prediction of the monthly rate of reduction of ALSFRS-r:
  3. SVC (70%), diagnosis delay (12 months), BMI (24), MMT (140) (sodium: 140):
  4. - NfL (100) + 4-HNE (20) + 8-oxo- dG (17) + Ferritin (170) = monthly adjusted rate: −0.72.
  5. - NfL (70) + 4-HNE (15) + 8-oxo- dG (16) + Ferritin (160) = monthly adjusted rate: −0.65.
  6. - NfL (40) + 4-HNE (5) + 8-oxo- dG (14) + Ferritin (150) = monthly adjusted rate: −0.56.
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