Table 3 Calculated pharmacokinetic parameters using a log-linear trapezoidal method for PASylated Adnectin C and the native protein.

From: Enhancing bioactivity, physicochemical, and pharmacokinetic properties of a nano-sized, anti-VEGFR2 Adnectin, through PASylation technology

Protein

T1/2 (min)

[AUC]0–∞ (µg.min/mL)

Elimination Rate Constant (h−1)

Clearance (mL/min)

PK factor

Adnectin C

49.41

1550.947

0.05

2.676889

1

Adnectin C-PAS#1(200)

226.2

30018.29

0.004

0.010707

4.578

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