Figure 2
From: The CDR1 and Other Regions of Immunoglobulin Light Chains are Hot Spots for Amyloid Aggregation
Consensus sequences (CONSENSUS-5) generated by the AmylPred2 tool from the analysis of the 6aJL2 protein with 10 different algorithms designed for predicting aggregation/fibrillogenic-prone sequences28. The individual prediction of each method is also shown. The regions of 6aJL2 protein with β-strands or helix conformation in the native state are indicated as in Fig. 1. The residue numbering and the location of the CDR/FR regions are according to Chothia and Lesk69. The graphical representations of 6aJL2 structure were prepared with PyMOL70, based on the structure contained in the PDB 2W0K.
