Figure 1 | Scientific Reports

Figure 1

From: Cross-disease analysis of Alzheimer’s disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases

Figure 1

Schematic representation of experimental design. The transcriptional signature associated to AD or T2DM was extracted from transcriptomic data of post-mortem cerebral cortices of AD or T2DM affected individuals as compared to controls. Network analysis was then performed with the reference protein-protein interaction (PPI) network derived from Biogrid data. The functionality analysis of the networks was then performed by testing over-represented Gene Ontology biological process terms and pathways. The relevance of autophagy, the most significant pathway identified by network analysis, was further validated in two animal models of AD.

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