Table 3 Results of the pathway analysis of the AD/T2DM overlapping network.

From: Cross-disease analysis of Alzheimer’s disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases

2.93E-09

5.29E-08

Signaling by NOTCH

Reactome

3.90E-09

6.69E-08

FoxO signaling pathway - Homo sapiens (human)

KEGG

7.18E-09

1.17E-07

Thyroid hormone signaling pathway - Homo sapiens (human)

KEGG

1.14E-07

1.53E-06

Macroautophagy

Reactome

1.59E-07

2.05E-06

Cellular Senescence

Reactome

1.15E-06

1.27E-05

Signaling by Wnt

Reactome

7.82E-06

6.79E-05

Regulation of autophagy - Homo sapiens (human)

KEGG

4.92E-05

0.000301243

Wnt signaling pathway - Homo sapiens (human)

KEGG

6.25E-05

0.000360329

Notch signaling pathway - Homo sapiens (human)

KEGG

0.000211397

0.0010285

Estrogen signaling pathway - Homo sapiens (human)

KEGG

0.000262185

0.001207105

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Reactome

0.000293703

0.001343203

Signaling by Interleukins

Reactome

0.000610253

0.002568306

Oxidative Stress Induced Senescence

Reactome

0.000693496

0.002848733

Central carbon metabolism in cancer - Homo sapiens (human)

KEGG

0.000864821

0.00342929

Neurotrophin signaling pathway - Homo sapiens (human)

KEGG

0.000990053

0.003773201

Signalling by NGF

Reactome

0.003406249

0.009736195

Innate Immune System

Reactome

0.009010442

0.018960624

Signaling by Leptin

Reactome