Table 2 Significant changes of 5-Ht2cr mRNA editing isoforms between PWScr^{p−/m5′LoxP} and wild type mice choroid plexus samples.

Pattern	Mean RPKM WT	Mean RPKM LoxP	Fold change WT/LoxP	P-value	SIG	pBH	WT %	LoxP %
CD	126959	104482	1.2	0.0009	***	0.02	12.6	11.8
AD	44104.5	33894	1.3	0.0013	**	0.0185	4.4	3.8
ABD	32223	18402	1.75	6.52E-05	****	0.0072	3.2	2.1
ED	23259	19153	1.2	0.03068	*	0.179	2.3	2.17
ACD	19010	14490	1.3	0.0043	**	0.053	1.9	1.6
ABCD	12761	5132	2.5	0.00027	***	0.0099	1.3	0.58
E	11309	17713	0.64	0.0062	**	0.0627	1.1	2
AC	5546	3450	1.6	0.00095	***	0.0175	0.55	0.3
AECD	3544	1277	2.8	0.0098	**	0.09	0.35	0.14
BCD	2631	535	4.9	0.024	*	0.156	0.26	0.06
CDH	262	79	3.3	0.019	*	0.1288	0.026	0.009
1AD	64.5	44	1.46	0.037	*	0.1973	0.006	0.005
ADG	61.5	46	1.34	0.044	*	0.2218	0.006	0.0052
ABDG	44	25	1.8	0.029	*	0.1792	0.004	0.0028
1ABD	35.5	22	1.6	0.012	*	0.0867	0.0035	0.0025
ABCDG	24.6	8	3.2	0.0013	**	0.0185	0.002	0.00087
ABCDF	21	6.5	3.2	0.00016	***	0.009	0.002	0.0007
3ABCD	19.5	7	2.9	0.005	**	0.0554	0.0019	0.00076
1ABCD	19	4	5	0.0003	***	0.0087	0.00185	0.0004
ABCDH	12	3	3.6	0.0112	*	0.0867	0.0012	0.0004
3AC	11	5	2.33	0.01	*	0.0867	0.001	0.00056

Pattern: Combinations of edited sites contribute to a variety 5-Ht2cr mRNA editing patterns. They are labeled according the designations of the contributing editing sites (Fig. 1A). Mean RPKM WT and LoxP: Calculated mean of RPKM values for wild type (WT) and, PWScr^{p−/m5′LoxP} (LoxP) samples. Fold change WT/LoxP: Fold change between wild type (WT) and PWScr^{p−/m5′LoxP} (LoxP) editing patterns. P-value: P-value of Student’s t-test. SIG: Graphpad formatting - asterisks describe p-values levels of statistical significance. pBH: “False Discovery Rate” correction for multiple comparisons. WT(%) and LoxP(%): The percentage of detected receptor isoforms in wild type (WT) and PWScr^{p−/m5′LoxP} (LoxP) mouse choroid plexuses, is indicated.

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