Figure 7 | Scientific Reports

Figure 7

From: Changes in the asymmetric distribution of cholesterol in the plasma membrane influence streptolysin O pore formation

Figure 7

Schematic illustration of cholesterol distribution in the PM. The PM contains three different types or pools of cholesterol: (I) SM-associated cholesterol in the outer leaflet; (II) SM-free cholesterol in the outer leaflet; and (III) cholesterol in the inner leaflet. ABCA1 flops cholesterol from the inner to the outer leaflet of the PM. The enhanced asymmetric distribution of cholesterol caused by exogenously expressed ABCA1 suppresses SLO pore formation.

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