Table 5 Diagnostic value of dCDT parameters and CERAD total scores in differentiating healthy individuals (HC) and patients with amnestic mild cognitive impairment (aMCI).

From: Diagnostic value of digital clock drawing test in comparison with CERAD neuropsychological battery total score for discrimination of patients in the early course of Alzheimer’s disease from healthy individuals

Model

ROC AUC

Selected Variable

Beta (β)

OR

95% CI (OR)

p-value

Lower

Upper

a) HC vs. aMCI

0.888

CDT score

1.864

6.452

3.671

11.340

<0.001

time in air

0.131

1.140

1.081

1.201

<0.001

time not painting

0.013

1.013

1.000

1.026

0.045

0.852

CERAD total score (cut-off 80.0 points)

0.137

0.872

0.842

0.903

<0.001

b) HC vs. aMCI with normal CDT scores

0.837

time in air

0.163

1.177

1.117

1.240

<0.001

0.848

CERAD total score (cut-off 80.0 points)

0.133

0.875

0.843

0.908

<0.001

c) HC vs. mAD

0.973

time in air

0.113

1.120

1.040

1.206

0.003

CDT score

2.554

12.860

5.892

28.068

<0.001

0.976

CERAD total score (cut-off 66.0 points)

0.225

0.799

0.750

0.851

<0.001

d) aMCI vs. mAD

0.852

total time

0.008

1.008

1.000

1.016

0.46

pressure/velocity relation

0.407

1.503

1.120

2.017

0.007

strokes per minute

−0.028

0.973

0.946

1.000

0.048

CDT scores

1.298

3.661

2.347

5.710

<0.001

0.846

CERAD total score (cut-off 58.0 points)

0.126

0.882

0.852

0.913

<0.001

  1. HC: healthy control individuals; aMCI: amnestic mild cognitive impairment; CDT: Clock Drawing Test; CERAD = Consortium to Establish a Registry for Alzheimer’s Disease neuropsychological battery. ROC = Receiver operating characteristics (ROC) curves; AUC = Area under the ROC curve; ß = Logistic regression coefficient, OR = Odds ratio, CI(OR) = Confidence Interval of odds ratio.
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