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Figure 1

From: Molecular imaging HDACs class IIa expression-activity and pharmacologic inhibition in intracerebral glioma models in rats using PET/CT/(MRI) with [18F]TFAHA

Figure 1

PET/CT/(MRI) of HDACs class IIa expression in intracerebral glioma models in rats. Representative series of coronal images of the rat brain bearing intracerebral U87-MG glioma (A) and 9L gliosarcoma (B). The position of sections relative to bregma is indicated in mm on T2-weighted MR images. [18F]TFAHA PET/CT images were obtained at 20 minutes post injection of radiotracer and co-registered with T2-weighted MR images. The levels of [18F]TFAHA accumulation in tumors and different structures of the brain were measured in SUV (C) and SUV ratio normalized by the SUV of the contralateral cortex (D) for 9L (N = 10) and U87-MG (N = 9) gliomas. PET/CT images are color-coded to standard uptake values (SUV). Data - mean ± SEM. Statistical significance was determined via one-way ANOVA, *denotes p < 0.05, **denotes p < 0.01, ***denotes p < 0.001.

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