Table 1 Potency and maximal response of the 36 identified GPR139 agonists in calcium mobilization assay in CHO-GPR139 cells.
From: Identification of a novel scaffold for a small molecule GPR139 receptor agonist
ID | Enamine ID | EC50 μM | pEC50 ± S.E.M. | Emax ± S.E.M. | n | Matches* |
|---|---|---|---|---|---|---|
AC224 | Z30029744 | 0.09 | 7.03 ± 0.02 | 106 ± 1 | 3 | 6 |
AC177 | Z1618891443 | 0.09 | 7.02 ± 0.11 | 103 ± 1 | 4 | 5 |
AC183 | Z352587398 | 0.18 | 6.74 ± 0.19 | 110 ± 10 | 3 | 5 |
AC197 | Z16669083 | 0.19 | 6.71 ± 0.14 | 103 ± 1 | 3 | 5 |
AC194 | Z18052622 | 0.21 | 6.68 ± 0.02 | 106 ± 4 | 3 | 5 |
AC4 | Z446416294 | 0.22 | 6.66 ± 0.06 | 116 ± 3 | 5 | 3 |
AC225 | Z13589494 | 0.28 | 6.56 ± 0.05 | 120 ± 5 | 3 | 5 |
AC178 | Z1618764723 | 0.28 | 6.55 ± 0.07 | 97 ± 5 | 3 | 5 |
AC209 | Z18053107 | 0.29 | 6.54 ± 0.17 | 107 ± 3 | 4 | 5 |
AC82 | Z352587564 | 0.29 | 6.54 ± 0.08 | 102 ± 6 | 3 | 4 |
AC202 | Z16669106 | 0.34 | 6.47 ± 0.09 | 102 ± 2 | 3 | 4 |
AC233 | Z14078826 | 0.34 | 6.47 ± 0.19 | 80 ± 6 | 3 | 5 |
AC191 | Z18052722 | 0.35 | 6.46 ± 0.16 | 99 ± 2 | 3 | 5 |
AC243 | Z14078663 | 0.35 | 6.45 ± 0.11 | 86 ± 5 | 3 | 4 |
AC206 | Z16668711 | 0.38 | 6.42 ± 0.06 | 94 ± 3 | 3 | 5 |
AC234 | Z14075523 | 0.38 | 6.42 ± 0.07 | 99 ± 3 | 3 | 5 |
AC7 | Z16668610 | 0.39 | 6.41 ± 0.12 | 112 ± 5 | 4 | 4 |
AC186 | Z14077796 | 0.41 | 6.39 ± 0.12 | 89 ± 5 | 3 | 4 |
AC241 | Z165543100 | 0.42 | 6.38 ± 0.06 | 88 ± 3 | 3 | 5 |
AC229 | Z14075450 | 0.43 | 6.36 ± 0.16 | 95 ± 2 | 4 | 4 |
AC205 | Z18052636 | 0.44 | 6.36 ± 0.14 | 100 ± 3 | 3 | 5 |
AC200 | Z18052594 | 0.46 | 6.34 ± 0.11 | 111 ± 5 | 3 | 5 |
AC220 | Z16668660 | 0.49 | 6.31 ± 0.01 | 103 ± 3 | 3 | 5 |
AC230 | Z14075785 | 0.49 | 6.31 ± 0.27 | 89 ± 1 | 3 | 4 |
AC137 | Z16669312 | 0.54 | 6.27 ± 0.08 | 92 ± 3 | 3 | 5 |
AC77 | Z336570670 | 0.60 | 6.22 ± 0.17 | 102 ± 4 | 3 | 5 |
AC210 | Z18052723 | 0.63 | 6.20 ± 0.24 | 115 ± 8 | 4 | 5 |
AC123 | Z54783382 | 0.74 | 6.13 ± 0.14 | 104 ± 1 | 3 | 5 |
AC187 | Z14077801 | 0.74 | 6.13 ± 0.22 | 102 ± 5 | 4 | 4 |
AC192 | Z16669294 | 0.75 | 6.12 ± 0.13 | 95 ± 1 | 3 | 4 |
AC14 | Z336589160 | 0.78 | 6.11 ± 0.12 | 93 ± 3 | 3 | 5 |
AC138 | Z16668376 | 0.79 | 6.10 ± 0.14 | 100 ± 5 | 4 | 5 |
AC134 | Z16669311 | 0.80 | 6.09 ± 0.15 | 103 ± 5 | 4 | 5 |
AC208 | Z18053097 | 0.88 | 6.05 ± 0.60 | 134 ± 26 | 3 | 5 |
AC76 | Z336570672 | 0.94 | 6.03 ± 0.10 | 97 ± 4 | 3 | 5 |
AC136 | Z16669296 | 0.99 | 6.01 ± 0.03 | 67 ± 6 | 3 | 5 |
