Table 4 Stimulated cytokines and psychological/symptom scores over time in patients and healthy volunteers.

From: Activation of Peripheral Blood CD4+ T-Cells in IBS is not Associated with Gastrointestinal or Psychological Symptoms

 

HV (n = 15) Initial visit

HV (n = 15) Return visit

IBS-D (n = 7) Initial visit

IBS-D (n = 7) Return visit

TNFα (pg/mL)

29.4 (12.9–138.2)

67.3 (23.7–118.8)

301.3 (90.1–588.1)

355.4 (69.5–614.9)

Anxiety

4.0 (3.8–5.3)

3.0 (2.0–6.3)

12.0 (8.0–16.0)

11.0 (4.0–14.0)

Depression

1.0 (0.8–2.3)

1.5 (0–3.0)

6.0 (2.0–8.0)

5.0 (4.0–8.0)

PHQ15

3.5 (1.0–4.3)

4.5 (2.8–8.0)

18 (11.0–20.0)

12 (10.0–19.0)*

IBS-SSS

12.8 (0–27.8)

18.3 (4.5–37.0)

306.0 (229.0–389.0)

265.5 (218.0–300.0)$

IBS-QOL

0 (0–2.5)

3.0 (0–6.3)

112.0 (81.0–150.0)

100.0 (48.0–145.0)

  1. HV: Healthy Volunteers. IBS-D: diarrhoea-predominant IBS, IBS-C: constipation-predominant IBS, IBS-M: IBS with mixed symptoms. PHQ15: Somatization score, IBS-SSS: IBS Symptom Severity Score. IBS-QOL: IBS-36 Quality of Life score. Note: for Anxiety, depression, PHQ15, IBS-SSS and IBS-QOL scores, n = 14 for HV. Raw data is shown. The change in cytokine concentration or symptom score was calculated by subtracting the initial measurement or score from the repeat and analysed. *p = 0.0012 vs HV; $p = 0.0098 vs HV.
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