Table 2 Association of haplotypes derived from F5 rs6025 (R534Q) and rs4524 (K858R) with VT risk.

From: Minor allele of the factor V K858R variant protects from venous thrombosis only in non-carriers of factor V Leiden mutation

  

Controls

Cases

OR (95%CI)

EDITH

 

(N = 1150)

(N = 1140)

 

H1

R534/K858

0.73

0.73

—

H2

Q534/K858

0.02

0.06

2.58 [1.85–3.61]

H3

R534/R858

0.25

0.21

0.85 [0.74–0.98]

EOVT

 

(N = 1228)

(N = 411)

 

H1

R534/K858

0.72

0.70

—

H2

Q534/K858

0.02

0.09

3.51 [2.38–5.17]

H3

R534/R858

0.26

0.21

0.86 [0.70–1.04]

FARIVE

 

(N = 575)

(N = 577)

 

H1

R534/K858

0.71

0.73

—

H2

Q534/K858

0.02

0.06

2.26 [1.41–3.61]

H3

R534/R858

0.27

0.21

0.78 [0.65–0.95]

MARTHA

 

(N = 1110)

(N = 1542)

 

H1

R534/K858

0.71

0.68

—

H2

Q534/K858

0.03

0.11

4.96 [3.67–6.71]

H3

R534/R858

0.26

0.21

0.83 [0.73–0.95]

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