Figure 3
(a–f) At 11 weeks after streptozotocin (STZ) induction, hyperglycemic SIRT3 germline knockout (Sirt3−/−) mice had significant retinal dysfunction based on their scotopic a-wave, scotopic b-wave, and photopic b-wave amplitudes compared to normoglycemic mice of the same genotype (N = 8–9/group; 2-way mixed ANOVA with Bonferroni post-hoc test). Hyperglycemic wild-type (Sirt3+/+) mice also exhibited similar retinal dysfunction compared to normoglycemic controls of the same genotype (N = 11–12/group; 2-way mixed ANOVA with Bonferroni post-hoc test). (g–l) At 11 weeks after STZ induction, hyperglycemic SIRT5 germline knockout (Sirt5−/−) and wild-type (Sirt5+/+) mice did not exhibit any retinal dysfunction compared to normoglycemic controls of the same genotype (N = 8–13/group; 2-way mixed ANOVA). Graphs depict mean ± S.E.M. (a–l) (*P < 0.05; **P < 0.01; ***P < 0.001; ^P < 0.0001).
