Table 3 Results from the pathway analysis based on the altered metabolites in manifest HD patients compared with controls. p-values < 0.05 and FDR values < 0.1 have been bolded.
Pathway | Coverage | p-value | FDR | Impact |
|---|---|---|---|---|
Aminoacyl-tRNA biosynthesis | 5/75 | 2.1 × 10 −4 | 0.014 | 0.0 |
Phenylalanine metabolism | 4/45 | 3.4 × 10 −4 | 0.014 | 0.173 |
Valine, leucine and isoleucine biosynthesis | 3/27 | 1.1 × 10 −3 | 0.029 | 0.040 |
Valine, leucine and isoleucine degradation | 3/40 | 3.4 × 10 −3 | 0.069 | 0.022 |
Purine metabolism | 4/92 | 5.0 × 10 −3 | 0.080 | 0.048 |
Phenylalanine, tyrosine and tryptophan metabolism | 2/27 | 0.018 | 0.246 | 0.008 |
Nitrogen metabolism | 2/39 | 0.037 | 0.420 | 0.0 |
