Figure 2 | Scientific Reports

Figure 2

From: Evaluation of Aminolevulinic Acid-Derived Tumor Fluorescence Yields Disparate Results in Murine and Spontaneous Large Animal Models of Lung Cancer

Figure 2

NSCLC models generate PPIX from 5-ALA in vivo: Mice bearing LKR flank tumors were randomized to variable doses of 5-ALA (0 mg/kg to 100 mg/kg), then imaged using the FloCam Imaging System. (a) Fluorescence of LKR NSCLC flank tumors was observed at higher dosing levels for up to 2 hours. (b) TBR of LKR flank tumors was calculated point and plotted over time. (c) Peak TBRs for LKR tumors were compared for dosing levels; of note, peak TBR for each concentration was observed 1 hour after drug delivery. The previous experiments were repeating in mice bearing A549 NSCLC xerographs, and the (d) TBR of A549 flank tumors was calculated point and plotted over time. (e) Peak TBRs for A549 tumors were compared for dosing levels. *p < 0.05, **p < 0.01, ns—not significant.

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