Figure 2
From: Collective influencers in protein interaction networks
Signaling genes and translational regulation of collective influencers (CI) in human protein interaction networks. (a) As for recipients of post-translational modifications, we observed that CIs were strongly enriched with methylation and acetylation targets in the combined network. While still significant, CIs were less enriched with phosphorylation targets. (b) While signaling proteins without membrane domains appeared strongly enriched with CIs, we found the opposite when we considered receptors that carried a trans-membrane protein in the combined network. (c) As a measure of translational regulation, we found that CIs in the combined network were significantly enriched with high copy number proteins, while they were depleted with low copy number proteins.
