Figure 4
From: Collective influencers in protein interaction networks
Evolutionary conservation of collective influencers (CI). In (a) we determined the propensity of (non-)CI proteins in the human combined network to be evolutionarily conserved in other organisms. Surprisingly, we observed that CIs were significantly more conserved in distant organisms. In (b) we mapped all human genes to evolutionarily conserved CIs in organism specific networks of interactions. Notably, human CIs were significantly enriched with CIs in other organisms (P < 10−10, Fisher’s exact test).
