Figure 2
Structure and electrostatics of conserpin-AATRCL. (A,D) X-ray crystal structure of native state conserpin-AATRCL represented as a cartoon. The breach and shutter regions are marked with black broken circles. (B–F) A comparison of electrostatic potential surfaces (blue = +ve, red = −ve) of (B,E) conserpin-AATRCL and (C,F) α1-AT. Both conserpin-AATRCL and α1-AT feature a large electropositive surface centred around the loop connecting strands 2 and 3 of β-sheet B (s2B and s3B) (B,C). A large surface patch between helix D and the RCL, highlighted with yellow broken circles, has a generally positive potential in conserpin-AATRCL (E), and negative potential in α1-AT (F).
