Table 1 Serum markers and body weight in animal model after 4MU treatment.

From: Hyaluronic acid inhibition by 4-methylumbelliferone reduces the expression of cancer stem cells markers during hepatocarcinogenesis

mg/kg/day

WT

HBV-TG

0

25

50

0

25

50

ALT (IU/L)

47 ± 20

73 ± 81

110 ± 136

186 ± 145

246 ± 176

314 ± 192

AST (IU/L)

131 ± 79

123 ± 40

141 ± 66

233 ± 133

270 ± 163

312 ± 177

LDH (IU/L)

925 ± 243

2002 ± 480**

2129 ± 638***

1453 ± 339

2083 ± 440**

2284 ± 992*

Weight (g)

40 ± 6

40 ± 4

40 ± 5

39 ± 5

37 ± 3

43 ± 8

  1. Statistical student’s t test: *p < 0.05, **p < 0.01, ***p < 0.001 compared to CTRL 0 mg/kg/day of each strain.
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