Figure 4
From: ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer’s disease
Characterization of ApoE fragments detected in the cortex of AD patients. (A) Illustrations of western blots of cortex from 2 AD patients revealed with 4 different anti-ApoE antibodies (ApoE 126-191, ApoE FL, ApoE Cter and ApoE 262–293). All fours antibodies recognized the 35 kDa form corresponding to the full length ApoE but only the anti-ApoE FL and the anti-ApoE 262–293 identified the 18 and 16 kDa forms, the smaller 12 kDa form was identified by three ApoE antibodies as compiled in (B,C). Schematic illustration of ApoE in control patient and of ApoE fragments formed only in AD patients. (D) Bar graph illustrating the effect of ApoE2/3 carriers versus ApoE4 carriers on the production of ApoE fragments. The number of samples analyzed is indicated in parentheses.
